Collaborators LoginOur vision is to be the premier provider of
information and technology to researchers and
clinicians in order to improve brain health
OUR MISSION
To provide broad access to biomarkers of neurological pathologies, essential enabling tools and information technology to accelerate the development and approval of effective therapies to treat Alzheimer’s and other neurodegenerative diseases.
ENIGMA'S Pipeline
Our pipeline focuses on potentially high-impact PET tracers for neurological disorders.
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Tracers for non-AD 4R Tauopathies, which may be useful for imaging Tau pathology in Progressive Supranuclear Palsy (PSP), Corticobasal syndrome (CBS), Familial frontal temporal dementias (fFTDs) and Muscarinic acetylcholine receptor M4 ligand [11C]MK-6884, which may be useful for measuring cholinergic tone alteration in AD patients
OUR FOCUS
Enabling Acceleration of
Disease Modifier Research
We devote our resources to enabling therapeutic disease modifier research by rallying support/validation from pharma and key academic opinion leaders worldwide and by sharing non-competitive data among our users group, our pharma and academic partners.
KEY COMPETENCIES:
- Partnership network development and maintenance: pharma, academia, and regional distributors
- Seamless technology transfer to establish an extensive worldwide production network of impeccable quality to support users group and clinical trials
- Robust quality, regulatory affairs, and data management
CERVEAU AND ENIGMA BIOMEDICAL GROUP (EBG)
MK-6240 Image Data Management
Revealing Insights
Evaluating Tau, using MK-6240, and other neurodegenerative pathologies to enhance decision making for AD drug development and ultimately clinical practice
NEWS
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Koscik RL, Betthauser TJ, Jonaitis EM, et al. Amyloid duration is associated with preclinical cognitive decline and tau PET. Alzheimers Dement (Amst). 2020;12(1):e12007. Doi: 10.1002/dad2.12007.
Therriault J, Benedet AL, Pascoal TA, et al. Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β. JAMA Neurol. 2020; 77(4):470-479. Doi: 10.1001/jamaneurol.2019.4421.
Koole M, Lohith TG, Valentine JL, et al. Preclinical safety evaluation and human dosimetry of [18F]MK-6240, a novel PET tracer for imaging neurofibrillary tangles. Mol Imaging Biol. 2020; 22(1):173-180. Doi: 10.1007/s11307-019-01367-w.
Laffon E, Buj S, de Clermont H, Marthan R. Fitting of late dynamic [18F]MK6240 PET scans for in vivo tau quantification. Eur J Nucl Med Mol Imaging. 2020; 47(1):7-8. Doi: 10.1007/s00259-019-04542-x.
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Lussier FZ, Pascoal TA, Chamoun M, et al. Mild behavioral impairment is associated with β -amyloid but not tau or neurodegeneration in cognitively intact elderly individuals. Alzheimers Dement. 2020; 16(1):192-199. Doi: 10.1002/alz.12007.
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Therriault J, Benedet AL, Pascoal TA, et al. APOEε4 potentiates the relationship between amyloid-β and tau pathologies. Mol Psychiatry. 2020; [Epub ahead of print]. Doi: 10.101038/s41380-020-0688-6.
Zou J, Tao S, Johnson A, et al. Microglial activation, but not tau pathology, is independently associated with amyloid positivity and memory impairment. Neurobiol Aging. 2020; 85:11-21. Doi: 10.1016/j.neurobiolaging.2019.09.019.
Aguero C, Dhaynaut M, Normandin MD, et al. Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue. Acta Neuropathol Commun. 2019; 7(1):37. Doi: 10.1186/s40478-019-0686-6.
Devanand DP, Andrews H, Kreisl WC, et al. Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: Protocol for a randomized, double-blind, placebo-controlled, treatment trial. BMJ Open. 2020; 10(2):e032112. Doi: 10.1136/bmjopen-2019-032112.
Murugan NA, Chiotis K, Rodriguez-Vieitez E, Lemoine L, Agren H, Nordberg A. Cross-interaction of tau PET tracers with monoamine oxidase B: Evidence from in silico modelling and in vivo imaging. Eur J Nucl Med Mol Imaging. 2019; 46(6):1369-1382. Doi: 10.1007/s00259-019-04305-8.
Leuzy A, Chiotis K, Lemoine L, et al. Tau PET imaging in neurodegenerative tauopathies – still a challenge. Mol Psychiatry. 2019; 24(8):1112-1134. Doi: 10.1038/s41380-018-0342-8.
Lohith TG, Bennacef I, Vandenberghe R, et al. Brain imaging of Alzheimer dementia patients and elderly controls with 18F-MK-6240, a PET tracer targeting neurofibrillary tangle pathology. J Nucl Med. 2019; 60(1):107-114. Doi: 10.2967/jnumed.118.208215.
Betthauser TJ, Cody KA, Zammit MD, et al. In vivo characterization and quantification of neurofibrillary tau PET radioligand MK-6240 in humans from Alzheimer’s disease dementia to young controls. J Nucl Med. 2019; 60(1):93-99. Doi: 10.2967/jnumed.118.209650.
Guehl NJ, Wooten DW, Yokell DL, et al. Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects. Eur J Nucl Med Mol Imaging. 2019; 46(10):2099-2111. Doi: 10.1007/s00259-019-04419-z.
Hopewell R, Ross K, Kostikov A, et al. A simplified radiosynthesis of [18F]MK-6240 for tau PET imaging. J Labelled Comp Radiopharm. 2019; 62(2):109-114. Doi: 10.1002/jlcr.3695.
Salinas C, Lohith TG, Purohit A, et al. Test-retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease. J Cereb Blood Flow Metab. 2019; [Epub ahead of print]. Doi: 10.1177/0271678X19887781.
Tago T, Toyohara J, Harada R, et al. Characterization of the binding of tau imaging ligands to melanin-containing cells: Putative off-target-binding site. Ann Nucl Med. 2019; 33(6):375-382. Doi: 10.1007/s12149-019-01344-x.
Murugan NA, Nordberg A, Agren H. Different positron emission tomography tau tracers bind to multiple binding sites on the tau fibril: Insight from computational modeling. ACS Chem Neurosci. 2018; 9(7):1757-1767. Doi: 10.1021/acschemneuro.8b00093.
Okamura N, Harada R, Ishiki A, et al. The development and validation of tau PET tracers: Current status and future directions. Clin Transl Imaging. 2018; 6(4):305-316. Doi: 10.1007/s40336-018-0290-y.
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Collier TL, Yokell DL, Livni E, et al. cGMP production of the radiopharmaceutical [18F]MK-6240 for PET imaging of human neurofibrillary tangles. J Labelled Comp Radiopharm. 2017; 60(5):263-269. Doi: 10.1002/jlcr.3496.
Hostetler ED, Walji AM, Zeng Z, et al. Preclinical characterization of 18F-MK-6240, a promising PET tracer for in vivo quantification of human neurofibrillary tangles. J Nucl Med. 2016; 57(10):1599-1606.
Walji AM, Hostetler ED, Selnick H, et al. Discovery of 6-(fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]-MK-6240): A positron emission tomography (PET) imaging agent for quantification of neurofibrillary tangles (NFTs). J Med Chem. 2016; 59(10):4778-89. Doi: 10.1021/acs.jmedchem.6b00166.